SNX-2112

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02907CAS No. ：908112-43-6Purity：98%

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CAS No.	908112-43-6	Cat. No.	BCP02907
Name	SNX-2112
Synonyms	SNX 2112;SNX2112;PF-04928473;PF 04928473;PF04928473;
SMILES
Chemical Name
Formula	C23H27F3N4O3	M. Wt	464.48
Purity	98%	Storage	Store at 4-8°C
Description	Treatment of BT-474 cells with 1 μM SNX-2112 results in down-regulation of HER2 expression within 3 to 6 hours of drug exposure with near-complete loss of HER2 expression by 10 hours. Treatment with SNX-2112 also results in a decline in total Akt expression. SNX-2112 inhibits cell proliferation with IC50 values ranging from 10 to 50 nM, in BT474, SKBR-3, SKOV-3, MDA-468, MCF-7 and H1650 cancer cells. And these antiproliferative effects are associated with hypophosphorylation of Rb, arrest of G1 and modest levels of apotosis. SNX-2112 competitively binds to the N-terminal adenosine triphosphate binding site of Hsp90. SNX-2112 induces apoptosis via caspase-8, -9, -3, and poly (ADPribose) polymerase cleavage. SNX-2112 inhibits cytokine-inducedAkt and extracellular signal-related kinase (ERK) activation and also overcomes the growth advantages conferred by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cells. SNX-2112 inhibits tube formation by human umbilical vein en