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IEM1754 dihydrobromide Chemical Structure

IEM1754 dihydrobromide

Data Sheet For research use only. Not for human use.
Cat. No. :BCP06096CAS No. :162831-31-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 162831-31-4 Cat. No. BCP06096
Name IEM1754 dihydrobromide
Synonyms IEM-1754;IEM 1754;
SMILES
Chemical Name
Formula C16H30N2.2HBr M. Wt 412.25
Purity 98% Storage Store at 4-8°C
Description IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits.IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization.
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