GLPG0634
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1206161-97-8 | Cat. No. | BCP08496 |
| Name | GLPG0634 | ||
| Synonyms | GLPG 0634; GLPG-0634; Filgotinib; | ||
| SMILES | O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2 | ||
| Chemical Name | |||
| Formula | C21H23N5O3S | M. Wt | 425.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GLPG0634, also known as Filgotinib, is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1- over JAK2-dependent signaling. GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. | ||
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