Saridegib
| CAS号 | 1037210-93-7 | 货号 | BCP25392 |
| 中文名 | Saridegib | ||
| 英文名 | Saridegib | ||
| 中文别名 | |||
| 英文别名 | IPI 926; IPI-926; IPI926;Patidegip; | ||
| 分子式 | C29H48N2O3S | 分子量 | 504.77 |
| 生物活性 | Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Smoothened/Smo | ||
结构式
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