Saridegib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP25392CAS号：1037210-93-7纯度：98%

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CAS号	1037210-93-7	货号	BCP25392
中文名	Saridegib
英文名	Saridegib
中文别名
英文别名	IPI 926; IPI-926; IPI926;Patidegip;
SMILES	CC1CC2C(C(C3(O2)CCC4C5CCC6CC(CCC6(C5CC4=C(C3)C)C)NS(=O)(=O)C)C)NC1
化学名称
分子式	C29H48N2O3S	分子量	504.77
纯度	98%	配送	惯例下常温包邮
产品描述	Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.