AC-264613
| CAS No. | 1051487-82-1 | Cat. No. | BCP25509 |
| Name | AC-264613 | ||
| Synonyms | AC 264613; AC264613; | ||
| Formula | C19H18BrN3O2 | M. Wt | 400.28 |
| Description | AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM. | ||
| Pathways | GPCR/G Protein | ||
| Targets | PAR | ||
Structure
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