I-CBP112
| CAS号 | 1640282-31-0 | 货号 | BCP20774 |
| 中文名 | I-CBP112 | ||
| 英文名 | I-CBP112 | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C27H36N2O5 | 分子量 | 468.59 |
| 生物活性 | I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin. | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Acetyltransferase Epigenetic Reader Domain | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！