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| CAS号 | 1640282-31-0 | 货号 | BCP20774 |
| 中文名 | I-CBP112 | ||
| 英文名 | I-CBP112 | ||
| 中文别名 | |||
| 英文别名 | |||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C27H36N2O5 | 分子量 | 468.59 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin. | ||
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