ND-630
| CAS号 | 1434635-54-7 | 货号 | BCP20893 |
| 中文名 | ND-630 | ||
| 英文名 | ND-630 | ||
| 中文别名 | |||
| 英文别名 | ND 630;ND630;NDI-010976; NDI 010976; NDI010976; GS-0976; GS0976; GS 0976;Firsocostat; | ||
| 分子式 | C28H31N3O8S | 分子量 | 569.63 |
| 生物活性 | ND-630, also known as GS-0976 and NDI-010976, is a potent ACC inhibitor. ND-630 nteracts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization and inhibit the enzymatic activity of both ACC isozymes, reduce fatty acid synthesis and stimulate fatty acid oxidation in cultured cells and in animals, and exhibit favorable drug-like properties. ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia. When administered chronically to Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction). | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ACC | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！