BMS 777607
| CAS No. | 1196681-44-3 | Cat. No. | BCP13190 |
| Name | BMS 777607 | ||
| Synonyms | BMS-777607;BMS777607; | ||
| Formula | C25H19ClF2N4O4 | M. Wt | 512.89 |
| Description | BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases. | ||
| Related Products | 1025720-94-8（BMS-777607） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | TAM Receptor | ||
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GAS6‐expressing and self‐sustaining cancer cells in 3D spheroids activate the PDK‐RSK‐mTOR pathway for survival and drug resistance
Publications Citing of Biochempartner's BMS 777607(CAS:1196681-44-3) |
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Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
Publications Citing of Biochempartner's BMS 777607(CAS:1196681-44-3) |
Structure
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