BMS-777607 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02303CAS No. ：1025720-94-8Purity：98%

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CAS No.	1025720-94-8	Cat. No.	BCP02303
Related Products	1196681-44-3 （BMS 777607）
Name	BMS-777607
Synonyms	1196681-44-3;BMS817378; BMS 817378; BMS-817378; BMS777607;BMS 777607; ASLAN 002; ASLAN-002; ASLAN002;
SMILES	O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=C(C=CN(C3=O)C4=CC=C(C=C4)F)OCC
Chemical Name
Formula	C25H19ClF2N4O4	M. Wt	512.89
Purity	98%	Storage	Store at 4-8°C
Description	BMS-777607, also known as BMS-817378 and ASLAN-002, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.