PF-543 HCl
| CAS号 | 1706522-79-3 | 货号 | BCP26198 |
| 中文名 | PF-543 HCl | ||
| 英文名 | PF-543 HCl | ||
| 中文别名 | |||
| 英文别名 | PF-543 hydrochloride; PF543 hydrochloride; PF 543 hydrochloride; | ||
| 分子式 | C27H32ClNO4S | 分子量 | 502.06 |
| 生物活性 | PF-543 HCl is the hydrochloride salt form of PF-543.PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | S1P Receptor | ||
结构式
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