PF-543 HCl 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP26198CAS号：1706522-79-3纯度：98%

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CAS号	1706522-79-3	货号	BCP26198
中文名	PF-543 HCl
英文名	PF-543 HCl
中文别名
英文别名	PF-543 hydrochloride; PF543 hydrochloride; PF 543 hydrochloride;
SMILES	OC[C@@H]1N(CC2=CC=C(COC3=CC(CS(=O)(C4=CC=CC=C4)=O)=CC(C)=C3)C=C2)CCC1.[H]Cl
化学名称
分子式	C27H32ClNO4S	分子量	502.06
纯度	98%	配送	惯例下常温包邮
产品描述	PF-543 HCl is the hydrochloride salt form of PF-543.PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.