GLPG1837
| CAS号 | 1654725-02-6 | 货号 | BCP23611 |
| 中文名 | GLPG1837 | ||
| 英文名 | GLPG1837 | ||
| 中文别名 | |||
| 英文别名 | GLPG 1837; GLPG1837; ABBV-974; ABBV 974; ABBV974; | ||
| 分子式 | C16H20N4O3S | 分子量 | 348.42 |
| 生物活性 | GLPG-1837, also known as ABBV-974, is a novel cystic fibrosis transmembrane conductance regulator (CFTR) potentiator1. GLPG1837 was generally safe and well tolerated in healthy subjects up to the highest dose of 800 mg twice daily for 2 weeks. GLPG1837 shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor, the first marketed potentiator. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | CFTR | ||
结构式
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