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CFTR

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CFTR

结构式 货号 产品名称 CAS号
MRT-5005 结构式
 BCP49476 MRT-5005 MRT-5005
MRT5005 is a drug designed to restore CFTR function by delivering correct copies of CFTR-encoded mRNA to the lungs.
RTC13 结构式
 BCP48256 RTC13 313530-30-2
RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Icenticaftor 结构式
 BCP21194 Icenticaftor 1334546-77-8
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively.
Crinecerfont hydrochloride 结构式
 BCP43623 Crinecerfont hydrochloride 321839-75-2
Crinecerfont is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein.
Elexacaftor R enantiomer 结构式
 BCP35907 Elexacaftor R enantiomer 2229860-99-3
Elexacaftor (VX-445,) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
Deutivacaftor 结构式
 BCP19794 Deutivacaftor 1413431-07-8
Deutivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator potentially for the treatment of cystic fibrosis.
Elexacaftor 结构式
 BCP29711 Elexacaftor 2216712-66-0
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
FDL169 结构式
 BCP30546 FDL169 1628416-28-3
FDL169 is an experimental therapy for cystic fibrosis (CF) that is being developed by Flatley Discovery Lab.
VX-659 结构式
 BCP29456 VX-659 2204245-48-5
VX-659 is a CFTR protein inhibitor.
ABBV-2222 结构式
 BCP25130 ABBV-2222 1918143-53-9
ABBV-2222, also known as GLPG2222, is a CFTR corrector being studied for the treatment of cystic fibrosis (CF).
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