XL-139甲磺酸盐
| CAS号 | XL139 | 货号 | BCP23569 |
| 中文名 | XL-139甲磺酸盐 | ||
| 英文名 | XL139 mesylate | ||
| 中文别名 | BMS-833923甲磺酸盐 ；BMS833923甲磺酸盐; | ||
| 英文别名 | BMS833923; BMS-833923; BMS 833923; XL139; XL-139; XL 139; | ||
| 分子式 | C32H35N5O7S2 | 分子量 | 665.78 |
| 生物活性 | BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Smoothened/Smo | ||
结构式
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