XL-139甲磺酸盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP23569CAS号：XL139纯度：98%

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CAS号	XL139	货号	BCP23569
中文名	XL-139甲磺酸盐
英文名	XL139 mesylate
中文别名	BMS-833923甲磺酸盐；BMS833923甲磺酸盐;
英文别名	BMS833923; BMS-833923; BMS 833923; XL139; XL-139; XL 139;
SMILES
化学名称
分子式	C32H35N5O7S2	分子量	665.78
纯度	98%	配送	惯例下常温包邮
产品描述	BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

XL-139甲磺酸盐 新