ND-646
| CAS号 | 1434639-57-2 | 货号 | BCP29105 |
| 中文名 | ND-646 | ||
| 英文名 | ND-646 | ||
| 中文别名 | |||
| 英文别名 | ND 646; ND646; | ||
| 分子式 | C28H32N4O7S | 分子量 | 568.64 |
| 生物活性 | ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. ND-646 had enhanced efficacy when combined with carboplatin, a common component of chemotherapeutic regimens used to treat human NSCLC. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ACC | ||
结构式
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