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ND-646 结构式

ND-646

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货号 :BCP29105CAS号 :1434639-57-2纯度:98%
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  • 基本信息与产品描述
CAS号 1434639-57-2 货号 BCP29105
中文名 ND-646
英文名 ND-646
中文别名
英文别名 ND 646; ND646;
SMILES
化学名称
分子式 C28H32N4O7S 分子量 568.64
纯度 98% 配送 惯例下常温包邮
产品描述 ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. ND-646 had enhanced efficacy when combined with carboplatin, a common component of chemotherapeutic regimens used to treat human NSCLC.
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