Pyrotinib
| CAS号 | 1269662-73-8 | 货号 | BCP29458 |
| 中文名 | Pyrotinib | ||
| 英文名 | Pyrotinib | ||
| 中文别名 | |||
| 英文别名 | SHR-1258; SHR1258; SHR 1258; | ||
| 分子式 | C32H31ClN6O3 | 分子量 | 583.08 |
| 生物活性 | Pyrotinibm, also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization. | ||
| 上下游产品 | 1397922-61-0（Pyrotinib maleate） 1246089-97-3（Pyrotinib Racemate ） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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