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Pyrotinib dimaleate 结构式

吡咯替尼二马来酸盐

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP29462CAS号 :1397922-61-0纯度:98%
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  • 基本信息与产品描述
CAS号 1397922-61-0 货号 BCP29462
关联产品 1269662-73-8(Pyrotinib) 1246089-97-3(Pyrotinib Racemate )
中文名 吡咯替尼二马来酸盐
英文名 Pyrotinib dimaleate
中文别名 二马来酸吡咯替尼;
英文别名 SHR-1258 dimaleate;SHR1258 dimaleate; SHR 1258 dimaleate;
SMILES O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[C@@H]5N(C)CCC5.O=C(O)/C=C\C(O)=O
化学名称
分子式 C40H39ClN6O11 分子量 815.22
纯度 98% 配送 惯例下常温包邮
产品描述 Pyrotinib Dimaleate is the dimaleate ester of pyrotinib, an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR, ErbB1 or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.
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