吡咯替尼二马来酸盐

  • 化学数据
CAS号 1397922-61-0 货号 BCP29462
中文名 吡咯替尼二马来酸盐
英文名 Pyrotinib dimaleate
中文别名 二马来酸吡咯替尼;
英文别名 SHR-1258 dimaleate;SHR1258 dimaleate; SHR 1258 dimaleate;
分子式 C40H39ClN6O11 分子量 815.22
  • 用途
生物活性 Pyrotinib Dimaleate is the dimaleate ester of pyrotinib, an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR, ErbB1 or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.
上下游产品 1269662-73-8(Pyrotinib) 1246089-97-3(Pyrotinib Racemate )
信号通路 Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway 
靶 点 EGFR HER2 

结构式

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