Mavorixafor trihydrochloride
| CAS号 | 2309699-17-8 | 货号 | BCP32916 |
| 中文名 | Mavorixafor trihydrochloride | ||
| 英文名 | Mavorixafor trihydrochloride | ||
| 中文别名 | |||
| 英文别名 | Mavorixafor 3HCl;AMD-070 trihydrochloride;AMD070 trihydrochloride; | ||
| 分子式 | C21H30Cl3N5 | 分子量 | 458.86 |
| 生物活性 | Mavorixafor is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. | ||
| 上下游产品 | 558447-26-0（Mavorixafor） 880549-30-4（Mavorixafor hydrochloride） | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | CXCR | ||
结构式
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