Mavorixafor trihydrochloride 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP32916CAS号：2309699-17-8纯度：98%

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CAS号	2309699-17-8	货号	BCP32916
关联产品	558447-26-0（Mavorixafor） 880549-30-4（Mavorixafor hydrochloride）
中文名	Mavorixafor trihydrochloride
英文名	Mavorixafor trihydrochloride
中文别名
英文别名	Mavorixafor 3HCl;AMD-070 trihydrochloride;AMD070 trihydrochloride;
SMILES	C1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl.Cl.Cl
化学名称
分子式	C21H30Cl3N5	分子量	458.86
纯度	98%	配送	惯例下常温包邮
产品描述	Mavorixafor is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas.