Mavorixafor 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07108CAS号：558447-26-0纯度：98%

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CAS号	558447-26-0	货号	BCP07108
关联产品	880549-30-4（Mavorixafor hydrochloride） 2309699-17-8（Mavorixafor trihydrochloride）
中文名	Mavorixafor
英文名	Mavorixafor
中文别名
英文别名	AMD11070; AMD-11070; AMD 11070;AMD 070; AMD070; X4P-001; X4P 001; X4P001; AMD-070;
SMILES	NCCCCN(CC1=NC2=C(N1)C=CC=C2)[C@@H]3C4=C(CCC3)C=CC=N4
化学名称
分子式	C21H27N5	分子量	349.48
纯度	98%	配送	惯例下常温包邮
产品描述	AMD-070(AMD 070) is useful for Anti HIV.AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.AMD11070 is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas.