BAY-598 R-isomer
| CAS号 | 1906920-28-2 | 货号 | BCP44956 |
| 中文名 | BAY-598 R-isomer | ||
| 英文名 | BAY-598 R-isomer | ||
| 中文别名 | |||
| 英文别名 | BAY 598 R-isomer; BAY598 R-isomer; | ||
| 分子式 | C22H20Cl2F2N6O3 | 分子量 | 525.34 |
| 生物活性 | BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 µM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar. | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Methyltransferase | ||
结构式
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