BAY-598 R-isomer 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44956CAS号：1906920-28-2纯度：98%

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CAS号	1906920-28-2	货号	BCP44956
中文名	BAY-598 R-isomer
英文名	BAY-598 R-isomer
中文别名
英文别名	BAY 598 R-isomer; BAY598 R-isomer;
SMILES	CCN(C1CN(N=C1C2=CC(=C(C=C2)Cl)Cl)C(=NC3=CC(=CC=C3)OC(F)F)NC#N)C(=O)CO
化学名称
分子式	C22H20Cl2F2N6O3	分子量	525.34
纯度	98%	配送	惯例下常温包邮
产品描述	BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 µM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar.