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Histone Methyltransferase

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Histone Methyltransferase

结构式 货号 产品名称 CAS号
MS023 dihydrochloride 结构式
 BCP49591 MS023 二盐酸盐 1992047-64-9
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.
Pociredir 结构式
 BCP49202 Pociredir 2490674-02-5
Pociredir is an embryonic ectoderm development (EED) protein inhibitor. Pociredir can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease.
TNG908 结构式
 BCP49197 TNG908 2760481-53-4
TNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier.
WDR5-IN-1 结构式
 BCP49073 WDR5-IN-1 2408842-51-1
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM.
MM-401 结构式
 BCP25182 MM-401 1442106-10-6
MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
AM-9747 结构式
 BCP46595 AM-9747 2691869-82-4
AM-9747 is a MTA Cooperative PRMT5 Inhibitor.
MRTX1719 HCl 结构式
 BCP46040 MRTX1719 HCl MRTX1719HCl
MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells.
EZM0414 结构式
 BCP45983 EZM0414 2411748-50-8
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay).
PF-06821497 结构式
 BCP45826 PF-06821497 1844849-10-0
EZH2 Inhibitor PF-06821497 is an orally available selective inhibitor of the histone lysine methyltransferase (HMT) enhancer of zeste homolog 2 (EZH2), with potential antineoplastic activity.
PRMT5-IN-3 结构式
 BCP45773 PRMT5-IN-3 2159123-14-3
PRMT5-IN-3 is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
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