(R)-CR8 trihydrochloride
| CAS No. | 1786438-30-9 | Cat. No. | BCP45442 |
| Name | (R)-CR8 trihydrochloride | ||
| Synonyms | CR8, (R)-Isomer trihydrochloride;(R)-CR8 triHCl;(R)-CR8 3HCl; | ||
| Formula | C24H32Cl3N7O | M. Wt | 540.92 |
| Description | (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K. | ||
| Related Products | 294646-77-8（(R)-CR8） | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
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