(R)-CR8 New
Data Sheet
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| CAS No. | 294646-77-8 | Cat. No. | BCP45443 |
| Related Products | 1786438-30-9（(R)-CR8 trihydrochloride） | ||
| Name | (R)-CR8 | ||
| Synonyms | CR8, (R)-Isomer; (R)-CR-8; (R)-CR 8; | ||
| SMILES | CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4 | ||
| Chemical Name | |||
| Formula | C24H29N7O | M. Wt | 431.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (R)-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. | ||
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