RO5126766
  • 化学数据
CAS号 946128-88-7 货号 BCP21067
中文名 RO5126766
英文名 RO5126766
中文别名
英文别名 RO 5126766; RO5126766; CH5126766; CH5126766; CH 5126766;
分子式 C21H18FN5O5S 分子量 471.46
  • 用途
生物活性 RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis.
信号通路 MAPK Pathway 
靶 点 MEK/ERK Raf 

结构式

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