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MEK/ERK

结构式 货号 产品名称 CAS号
APS-2-79 结构式
 BCP24938 APS-2-79 2002381-25-9
APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.
Selumetinib sulfate 结构式
 BCP36547 硫酸司美替尼 943332-08-9
Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity.
ASN007 benzenesulfonate 结构式
 BCP48484 ASN007 benzenesulfonate 2055597-39-0
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.
ASN007 结构式
 BCP48479 ASN007 2055597-12-9
ASN007 is a potent and oral of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC50 values. ASN007 has the potential to be used to study cancers driven by RAS mutations.
ONC-201 Dihydrochloride 结构式
 BCP46830 ONC-201 Dihydrochloride 1638178-82-1
ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
PD184161 结构式
 BCP46466 PD184161 212631-67-9
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
Rineterkib hydrochloride 结构式
 BCP43938 Rineterkib hydrochloride 1715025-34-5
Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
BAY-885 结构式
 BCP34724 BAY-885 2307249-33-6
BAY-885 is a highly potent and selective ERK5 inhibitor.
Rineterkib 结构式
 BCP38204 Rineterkib 1715025-32-3
Rineterkib is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway.
trans-Zeatin Hydrochloride 结构式
 BCP36686 反-玉米素盐酸盐 6025-81-6
trans-Zeatin Hydrochloride can be used in biological study and therapeutic use for plant-growth factors as cell-proliferating agents for promotion of wound healing.
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