沃替西汀
| CAS号 | 508233-74-7 | 货号 | BCP05996 |
| 中文名 | 沃替西汀 | ||
| 英文名 | Vortioxetine | ||
| 中文别名 | |||
| 英文别名 | Lu AA 21004；LuAA21004； Lu-AA21004； Lu AA21004； AA21004; AA-21004; AA 21004; | ||
| 分子式 | C18H22N2S | 分子量 | 298.45 |
| 生物活性 | Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U.S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so-called "serotonin modulator and stimulator." It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM; Norepinephrine transporter (NET) blocker — Ki = 113 nM; 5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%; 5-HT1B receptor partial agonist — Ki = 33 nM; 5-HT1D receptor antagonist — Ki = 54 nM; 5-HT3A receptor antagonist — Ki = 3.7 nM; 5-HT7 receptor antagonist — Ki = 19 nM. | ||
| 上下游产品 | 960203-27-4（沃替西汀氢溴酸盐） | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | 5 HT Receptor/Serotonin Receptor | ||
结构式
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