塞来西布
| CAS号 | 1146699-66-2 | 货号 | BCP01770 |
| 中文名 | 塞来西布 | ||
| 英文名 | Avagacestat | ||
| 中文别名 | |||
| 英文别名 | BMS-708163;BMS708163;BMS 708163; | ||
| 分子式 | C20H17ClF4N4O4S | 分子量 | 520.89 |
| 生物活性 | Avagacestat, also known as BMS-708163, is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. | ||
| 信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| 靶 点 | Gamma secretase Notch | ||
结构式
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