雷替曲塞
| CAS号 | 112887-68-0 | 货号 | BCP02874 |
| 中文名 | 雷替曲塞 | ||
| 英文名 | Raltitrexed | ||
| 中文别名 | 兰替特噻; | ||
| 英文别名 | TDX;ZD 1694;ZD1694;ZD-1694;Tomudex;D1694; ICID1694; D-1694; ICID-1694; D 1694; ICID 1694;; | ||
| 分子式 | C21H22N4O6S | 分子量 | 458.49 |
| 生物活性 | Raltitrexed (Tomudex) is an antimetabolite drug used in cancer chemotherapy. Raltitrexed (Tomudex) is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting Dihydrofolate reductase, an enzyme used in the synthesis of tetrahydrofolate, thereby preventing the synthesis of thymidylate.In a study, there was an inverse relationship between reduced folate cellular content and raltitrexed IC50; this relationship did not, however, reach statistical significance. The only significant relationship was found between basal cellular folylpolyglutamate synthetase activity and raltitrexed IC50r = -0.56, p = 0.03. Tumor cells with a relatively high folylpolyglutamate synthetase activity were more sensitive to raltitrexed cytotoxic effects and vice versa. | ||
| 信号通路 | Cell Cycle/DNA Damage Apoptosis Pathway | ||
| 靶 点 | Thymidylate Synthase DNA/RNA Synthesis Antimetabolite | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！