雷替曲塞新

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货号：BCP02874CAS号：112887-68-0纯度：98%

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CAS号	112887-68-0	货号	BCP02874
中文名	雷替曲塞
英文名	Raltitrexed
中文别名	兰替特噻;
英文别名	TDX;ZD 1694;ZD1694;ZD-1694;Tomudex;D1694; ICID1694; D-1694; ICID-1694; D 1694; ICID 1694;;
SMILES
化学名称
分子式	C21H22N4O6S	分子量	458.49
纯度	98%	配送	惯例下常温包邮
产品描述	Raltitrexed (Tomudex) is an antimetabolite drug used in cancer chemotherapy. Raltitrexed (Tomudex) is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting Dihydrofolate reductase, an enzyme used in the synthesis of tetrahydrofolate, thereby preventing the synthesis of thymidylate.In a study, there was an inverse relationship between reduced folate cellular content and raltitrexed IC50; this relationship did not, however, reach statistical significance. The only significant relationship was found between basal cellular folylpolyglutamate synthetase activity and raltitrexed IC50r = -0.56, p = 0.03. Tumor cells with a relatively high folylpolyglutamate synthetase activity were more sensitive to raltitrexed cytotoxic effects and vice versa.

雷替曲塞 新