Fostamatinib disodium

CAS No.	1025687-58-4	Cat. No.	BCP02850
Name	Fostamatinib disodium
Synonyms	prodrug of R-406;R935788 sodium;R-788;R 788;R788 disodium;R935788; R-935788; R 935788;
Formula	C23H24FN6O9P.2Na	M. Wt	624.42

Description	Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. R935788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. R406 (in vitro active form of R935788) selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a variety of diffuse large B-cell lymphoma (DLBCL) cell lines with EC50 values ranging from 0.8 μM to 8.1 μM.R406 treatment reduces basal phosphorylation of BLNK, Akt, glycogen synthase kinase-3 (GSK-3), forkhead box O (FOXO) and ERK not only in cells with high (TCL-002) but also in cells with low levels of phosphorylated Syk (TCL1-551).
Related Products	901119-35-5（Fostamatinib） 914295-16-2（Fostamatinib disodium hexahydrate）
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	Syk

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