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Fostamatinib disodium hexahydrate Chemical Structure

Fostamatinib disodium hexahydrate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP14298CAS No. :914295-16-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 914295-16-2 Cat. No. BCP14298
Related Products 1025687-58-4(Fostamatinib disodium) 901119-35-5(Fostamatinib)
Name Fostamatinib disodium hexahydrate
Synonyms R788 disodium hexahydrate;R 788 disodium hexahydrate;R-788 disodium hexahydrate;
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+]
Chemical Name
Formula C23H36FN6Na2O15P M. Wt 732.52
Purity 98% Storage Store at 4-8°C
Description Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
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