Fostamatinib disodium hexahydrate New
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CAS No. | 914295-16-2 | Cat. No. | BCP14298 |
Related Products | 1025687-58-4(Fostamatinib disodium) 901119-35-5(Fostamatinib) | ||
Name | Fostamatinib disodium hexahydrate | ||
Synonyms | R788 disodium hexahydrate;R 788 disodium hexahydrate;R-788 disodium hexahydrate; | ||
SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+] | ||
Chemical Name | |||
Formula | C23H36FN6Na2O15P | M. Wt | 732.52 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. |
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