依伐卡托

  • 化学数据
CAS号 873054-44-5 货号 BCP01857
中文名 依伐卡托
英文名 Ivacaftor
中文别名 依法卡托;艾伐卡托;
英文别名 VX-770;VX770;VX 770;Kalydeco;
分子式 C24H28N2O3 分子量 392.49
  • 用途
生物活性 Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel will be open and allow chloride ions pass through the channel pore.
信号通路 Ion Channel/Membrane Transporter 
靶 点 CFTR 

结构式

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