马赛替尼
| CAS号 | 790299-79-5 | 货号 | BCP01820 |
| 中文名 | 马赛替尼 | ||
| 英文名 | Masitinib | ||
| 中文别名 | |||
| 英文别名 | AB1010;Masivet;AB-1010;AB 1010; | ||
| 分子式 | C28H30N6OS | 分子量 | 498.65 |
| 生物活性 | Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | PDGFR c Kit FAK | ||
结构式
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