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CAS号 | 790299-79-5 | 货号 | BCP01820 |
中文名 | 马赛替尼 | ||
英文名 | Masitinib | ||
中文别名 | |||
英文别名 | AB1010;Masivet;AB-1010;AB 1010; | ||
SMILES | O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4 | ||
化学名称 | |||
分子式 | C28H30N6OS | 分子量 | 498.65 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). |
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