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PDGFR

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PDGFR

结构式 货号 产品名称 CAS号
Crenolanib besylate 结构式
 BCP24113 Crenolanib besylate 670220-93-6
Crenolanib is a n orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation.
PD 161570 结构式
 BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
Tyrphostin AG1433 结构式
 BCP48941 Tyrphostin AG1433 168835-90-3
Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).
KG5 结构式
 BCP46930 KG5 877874-85-6
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
SU16F 结构式
 BCP46277 SU16F 251356-45-3
SU16F is a potent and selective platelet-derived growth factor receptor ß (PDGFRß) inhibitor.
SU4984 结构式
 BCP44116 SU4984 186610-89-9
SU4984 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM).
PD089828 结构式
 BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
CGP-53716 结构式
 BCP34642 CGP-53716 152459-94-4
CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR.
Tyrosine kinase-IN-1 结构式
 BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
Sennoside B 结构式
 BCP14631 番泻苷 B 128-57-4
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
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