二甲苯磺酸拉帕替尼
CAS号 | 388082-78-8 | 货号 | BCP01815 |
中文名 | 二甲苯磺酸拉帕替尼 | ||
英文名 | Lapatinib Ditosylate | ||
中文别名 | |||
英文别名 | Tykerb Ditosylate;GW572016 ditosylate; GW2016 ditosylate; | ||
分子式 | C29H26ClFN4O4S.2(C7H8O3S) | 分子量 | 925.46 |
生物活性 | Lapatinib Ditosylate is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. | ||
上下游产品 | 231277-92-2(拉帕替尼) 388082-77-7(二对甲苯磺酸拉帕替尼) | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
靶 点 | EGFR HER2 |
结构式
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