MK-2206 2HCl
| CAS号 | 1032350-13-2 | 货号 | BCP01821 |
| 中文名 | MK-2206 2HCl | ||
| 英文名 | MK-2206 2HCl | ||
| 中文别名 | |||
| 英文别名 | MK2206;MK 2206; | ||
| 分子式 | C25H23Cl2N5O | 分子量 | 480.39 |
| 生物活性 | MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. | ||
| 上下游产品 | 1032349-93-1（MK-2206） | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | AKT | ||
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Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells
购于瀚香生物(Biochempartner)的MK-2206 2HCl(CAS:1032350-13-2)被引用 |
结构式
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