MK-2206 2HCl

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01821CAS号：1032350-13-2纯度：98%

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CAS号	1032350-13-2	货号	BCP01821
关联产品	1032349-93-1（MK-2206）
中文名	MK-2206 2HCl
英文名	MK-2206 2HCl
中文别名
英文别名	MK2206;MK 2206;
SMILES
化学名称
分子式	C25H23Cl2N5O	分子量	480.39
纯度	98%	配送	惯例下常温包邮
产品描述	MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death.