MK-2206 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP20200CAS号：1032349-93-1纯度：98%

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CAS号	1032349-93-1	货号	BCP20200
关联产品	1032350-13-2（MK-2206 2HCl）
中文名	MK-2206
英文名	MK-2206
中文别名
英文别名	MK 2206;MK2206;
SMILES	C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N
化学名称
分子式	C25H21N5O	分子量	407.48
纯度	98%	配送	惯例下常温包邮
产品描述	MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer.