曲氟胸苷
| CAS号 | 70-00-8 | 货号 | BCP09147 |
| 中文名 | 曲氟胸苷 | ||
| 英文名 | Trifluridine | ||
| 中文别名 | |||
| 英文别名 | FTD;Viroptic;Trifluorothymidine;NSC 529182;NSC 75520;NSC-75520; | ||
| 分子式 | C10H11F3N2O5 | 分子量 | 296.2 |
| 生物活性 | in vitro: When HeLa cells were treated with TFT at a concentration of 1 uM (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT . SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) . in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed . | ||
| 上下游产品 | 733030-01-8（Trifluridine-tipiracil hydrochloride mixture） | ||
| 信号通路 | Cell Cycle/DNA Damage Apoptosis Pathway | ||
| 靶 点 | Thymidylate Synthase Antimetabolite | ||
结构式
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