曲氟胸苷

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09147CAS号：70-00-8纯度：98%

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CAS号	70-00-8	货号	BCP09147
关联产品	733030-01-8（Trifluridine-tipiracil hydrochloride mixture）
中文名	曲氟胸苷
英文名	Trifluridine
中文别名
英文别名	FTD;Viroptic;Trifluorothymidine;NSC 529182;NSC 75520;NSC-75520;
SMILES
化学名称
分子式	C10H11F3N2O5	分子量	296.2
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: When HeLa cells were treated with TFT at a concentration of 1 uM (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT . SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) . in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed .