Fostamatinib disodium hexahydrate

CAS No.	914295-16-2	Cat. No.	BCP14298
Name	Fostamatinib disodium hexahydrate
Synonyms	R788 disodium hexahydrate;R 788 disodium hexahydrate;R-788 disodium hexahydrate;
Formula	C23H36FN6Na2O15P	M. Wt	732.52

Description	Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
Related Products	1025687-58-4（Fostamatinib disodium） 901119-35-5（Fostamatinib）
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	Syk

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