ONC201
| CAS号 | 1616632-77-9 | 货号 | BCP14991 |
| 中文名 | ONC201 | ||
| 英文名 | ONC201 | ||
| 中文别名 | |||
| 英文别名 | ONC-201;ONC 201;TIC-10;TIC 10;TIC10;Dordaviprone; | ||
| 分子式 | C24H26N4O | 分子量 | 386.49 |
| 生物活性 | Akt/ERK Inhibitor ONC201 is a water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier. | ||
| 上下游产品 | 41276-02-2（TIC10 Analogue） 1638178-82-1（ONC-201 Dihydrochloride） | ||
| 信号通路 | Apoptosis Pathway PI3K/Akt/mTOR MAPK Pathway | ||
| 靶 点 | TNF Receptor MEK/ERK AKT | ||
结构式
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